NEWARK, DEL.-- QPS Holdings, LLC (QPS), a global contract research organization (CRO) that provides discovery, preclinical, bioanalysis, clinical trials, and clinical research services, is rapidly expanding its mass spectrometry capacity, adding 13 LC-MS machines in just 15 months at their laboratories in Newark, Delaware (USA) and Groningen, The Netherlands (NL).

This expansion includes the impressive growth seen in 2023, when QPS installed seven additional UPLC-(HR)MS/MS tandem instruments - four triple quadrupoles, one QTRAP, and two quadrupole time-of-flight high-resolution mass spectrometers (HRMS). The addition of the two new UPLC-HRMS/MS machines, one in the Netherlands and one in the USA, brings QPS to a total of five UPLC-HRMS/MS dedicated to GLP/GCP quantitation of oligonucleotide therapeutics and oligonucleotide metabolite identification to support the explosive growth of this drug modality in both the USA and Europe. Having HRMS capabilities on both continents eliminates the challenges of obtaining CITES permits to ship critical oligonucleotide therapeutics samples from the USA to Europe and vice versa.

Continuing into 1Q 2024, QPS announces the expansion of its USA LC-MS fleet with the addition of six triple quadrupoles coupled to ultra-high performance liquid chromatography (UPLC) or supercritical fluid chromatography (SFC). The addition of SFC-MS/MS brings a new dimension to the QPS chiral separation capabilities, which are critical in supporting clients to develop leading-edge new therapies to address critical global healthcare needs.

“QPS is dedicated to excellence in bioanalysis and DMPK laboratory work. Our clients recognize our commitment and continue to expand their relationships with us. QPS Subject Matter Experts are some of the best in the industry and this new equipment will provide the capacity for them to expand their relationships with our important biotech and pharmaceutical clients,” said Zamas Lam, PhD, Global Head of Bioanalytical (Mass Spec) & Preclinical Development, QPS LLC. “This is what drives our enthusiasm,” said Lam.

With this additional capacity, the QPS Global Bioanalytical and DMPK laboratories in the USA and the Netherlands can support current and new biotech and pharmaceutical clients in drug discovery and development of gene therapies and protein drugs. This group’s expertise lies in the quantitation of oligonucleotides, peptides, intact proteins, and highly hydrophilic low-molecular-weight metabolite biomarkers by UPLC-HRMS, or by immunoaffinity UPLC-MS/MS, or by hybridization-LC-fluorescence.